Effect of long-term administration of stobadine to rats on selective variables of spontaneous behaviour of their offspring.

Long-term Developmental Effects of Lactational Exposure to Lead Acetate on Ovary in Offspring Wistar Rats

Quinapril Attenuates the Effect of Long-Term L-NAME Administration on the Vascular Reactivity of Diabetic Rats

Angiotensin-converting enzyme (ACE) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. The present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (STZ)-diabetic rats treated for 4 weeks with nitro-L-arginine-methyl ester (L-NAM...

Effect of long-term oral administration of thyroxine on morphology of the gastrointestinal tract in broiler breeder hens

Published data on 4-week-long administration of extra thyroxine (T4) in broiler breeder hens to alleviate the cold-induced ascites in their offspring suggested that long-term maternal hyperthyroidism would affect the gastrointestinal tract morphology. Broiler breeder hens (n=70) were reared in individual cages and allotted to control and hyperthyroid groups (five replicates of seven ...

Repeated administration of cannabinoid receptor agonist and antagonist impairs short and long term plasticity of rat’s dentate gyrus in vivo

Introduction: The effects of cannabinoids (CBs) on synaptic plasticity of hippocampal dentate gyrus neurons have been shown in numerous studies. However, the effect of repeated exposure to cannabinoids on hippocampal function is not fully understood. In this study, using field potential recording, we investigated the effect of repeated administration of the nonselective CB receptor agonist WIN5...

Effects of Venlafaxine & Methadone Alone and in Combination with Spontaneous Morphine withdrawal Syndrome & Pain Sensation in Rats

Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in dr...